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T2DM Family Hx Tied to Higher Prediabetes Risk in Non-Obese
Family history of type 2 diabetes ups prediabetes risk by 26 percent, but link only seen in non-obese

TUESDAY, Aug. 27 (HealthDay News) -- Having a family member with type 2 diabetes is associated with a higher risk of prediabetes, but only among the non-obese, according to a study published online Aug. 27 in Diabetologia.

Robert Wagner, from the German Center for Diabetes Research in Neuherberg, and colleagues analyzed whether having at least one first-degree relative with type 2 diabetes is associated with prediabetes in 8,106 individuals without diabetes of European origin, where 5,482 had normal glucose tolerance and 2,624 had impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG).

The researchers found that, after adjusting for sex, age, and body mass index, a family history of diabetes was associated with a significantly higher risk of prediabetes (odds ratio [OR], 1.26 for IGT and/or IFG). A family history of diabetes was associated with a higher risk of IGT alone (OR, 1.25), IFG alone (OR, 1.37), and both (OR, 1.64). However, the higher risk of prediabetes was only observed in the non-obese (those with a body mass index <30 kg/m²).

"We found that family history of diabetes is an important risk factor for prediabetes, especially for combined IGT and IFG," Wagner and colleagues conclude. "Its relevance seems to be more evident in the non-obese."

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