ARCHIVE SEARCH
      -OR-  
 
  NEWS CHANNELS
Fitness News
Asthma Allergy News
 > Diabetes News
Women's Health News
Men's Health News

  MY NEWS
Personal Archive
My Account

  ABOUT THIS NEWSFEED
About Us
Advertise With Us
Feed Your Site
Contact Us


Site Map
RSS News Feed 

  Website development & hosting
   by Cyber Software Solutions

 
Islet Autoantibodies Predict Type 1 Diabetes Progression
Most at-risk children with multiple autoantibodies will develop type 1 diabetes

TUESDAY, June 18 (HealthDay News) -- Most children genetically at risk of developing type 1 diabetes will develop the disease if they seroconvert to multiple islet autoantibodies, according to a study published in the June 19 issue of the Journal of the American Medical Association.

Anette G. Ziegler, M.D., from Technische Universität München in Neuherberg, Germany, and colleagues prospectively investigated the rate of progression to type 1 diabetes after islet autoantibody seroconversion in 13,377 children genetically at risk in the United States (Colorado), Finland, and Germany.

After a follow-up of 10 years, the researchers found that the rate of progression to type 1 diabetes was 69.7 percent of 585 children with multiple islet autoantibodies. Progression was faster for those who seroconverted before 3 years of age (hazard ratio [HR], 1.65; 10-year risk, 74.9 percent), those with the human leukocyte antigen genotype DR3/DR4-DQ8 (HR, 1.35; 10-year risk, 76.6 percent), and females (HR, 1.28; 10-year risk, 74.8 percent). In contrast, the rate of progression was 14.5 percent for children with a single islet autoantibody and 0.4 percent by 15 years of age for children with no autoantibodies.

"The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years," Ziegler and colleagues conclude.

One author is a board member of Novo Nordisk Diabetes and Medtronic Nordic.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)



Health News Copyright © 2013 HealthDay. All rights reserved.


Back to Top Stories
  GOOGLE ADS