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ENDO: Skipping Breakfast Tied to Insulin Resistance in Obese
Obese women have higher insulin, free fatty acid total AUC after one day of skipping breakfast

MONDAY, June 17 (HealthDay News) -- In overweight or obese women, missing breakfast is associated with insulin resistance, according to a study presented at the annual meeting of The Endocrine Society, held from June 15 to 18 in San Francisco.

Elizabeth A. Thomas, M.D., from the University of Colorado Denver, and colleagues conducted a randomized cross-over trial to assess the metabolic responses to skipping breakfast in a group of nine overweight and obese women. On two study days, one month apart, the participants either ate breakfast or had no breakfast, and then consumed a standard lunch four hours later. Blood sampling was performed every 30 minutes for three hours after lunch.

The researchers observed no difference in pre-lunch insulin or glucose between the conditions, but in the no-breakfast condition, the insulin and glucose total area under the curve (AUC) was higher than in the breakfast condition. Pre-lunch free fatty acids were higher in the no-breakfast versus the breakfast condition, while pre-lunch triglycerides were lower in the no-breakfast condition. In the no-breakfast condition, the total and incremental AUCs for free fatty acids were higher than in the breakfast condition. The triglyceride total AUC was lower in the no-breakfast condition, but the incremental AUC did not differ between the conditions.

"Our study found that acute insulin resistance developed after only one day of skipping breakfast," Thomas said in a statement. "This information should help health care providers in counseling patients as to why it is better to eat a healthy, balanced breakfast than to skip breakfast."

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