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April 2013 Briefing - Diabetes & Endocrinology

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for April 2013. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Social Network Interests Can Predict Obesity Prevalence

TUESDAY, April 30 (HealthDay News) -- Online social interests can predict the prevalence of obesity in a given geographical area, according to a study published online April 24 in PLOS ONE.

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Renewed Efforts From AAFP to Repeal OTC Provision in ACA

TUESDAY, April 30 (HealthDay News) -- Members of the American Academy of Family Physicians (AAFP) and other medical associations are urging further consideration of Section 9003 of the Patient Protection and Affordable Care Act (ACA) that requires holders of tax-preferred health care accounts to obtain a physician's prescription to use funds from those accounts to pay for over-the-counter (OTC) medications. The concerns have been laid out in a letter to the chair and the ranking member of the House Committee on Ways and Means.

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Mediterranean Diet Adherence Cuts Cognitive Impairment

MONDAY, April 29 (HealthDay News) -- Greater adherence to a Mediterranean diet (MeD) is associated with a lower likelihood of incident cognitive impairment (ICI), especially among those without diabetes, according to a study published in the April 30 issue of Neurology.

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Zoledronic Acid Linked to Early Increase in Sclerostin Levels

MONDAY, April 29 (HealthDay News) -- Women with postmenopausal osteoporosis treated with zoledronic acid show an early increase in serum levels of the negative regulator of bone formation, sclerostin, that return close to baseline after 360 days, according to a study published online April 17 in the Journal of Clinical Endocrinology & Metabolism.

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FDA Announces New Network to Focus Exclusively on Patients

MONDAY, April 29 (HealthDay News) -- The U.S. Food and Drug Administration has announced the launch of a new interactive tool for educating patients, their advocates, and consumers about the processes involved in medication development.

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Gene Variants Link to Insulin Resistance Based on Diet

FRIDAY, April 26 (HealthDay News) -- Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in Diabetes Care.

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Medical Interns Spending Less Time With Patients

FRIDAY, April 26 (HealthDay News) -- Medical interns are spending less time with patients and more time at a computer since new rules limiting total work hours were instituted in 2011, according to a study published online April 18 in the Journal of General Internal Medicine.

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Teen Moms More Likely to Be Subsequently Overweight

FRIDAY, April 26 (HealthDay News) -- Teen mothers are more likely to be overweight or obese later in life compared to women who do not give birth as a teen, according to a study published online April 15 in the American Journal of Obstetrics & Gynecology.

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Post-Fracture Targeting Boosts Osteoporosis Management

FRIDAY, April 26 (HealthDay News) -- A mail-based intervention targeting patients with recent frailty fractures and their physicians is a more cost-effective means of osteoporosis management than usual care, according to a simulation-based study published online April 17 in the Journal of Clinical Endocrinology & Metabolism.

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Report Updates Impact of Hypoglycemia in Diabetes

FRIDAY, April 26 (HealthDay News) -- An update of the current state of knowledge about the impact of hypoglycemia on patients with diabetes reviews outcomes, strategies to prevent hypoglycemia, and current knowledge gaps, and has been published in the May issue of Diabetes Care.

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Saturday Marks Sixth Annual Rx Drug Take-Back Day

FRIDAY, April 26 (HealthDay News) -- United States residents across the nation will have an opportunity to safely and anonymously unload expired, unwanted prescription medications on Saturday, April 27, during the sixth annual National Prescription Drug Take-Back Day.

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Risk of Delay in Response to Patient E-Mails Up Over Weekend

THURSDAY, April 25 (HealthDay News) -- The risk of delays in opening and responding to primary care patient e-mail communication is significantly worse at the weekends, according to a study published in the April/June issue of Quality Management in Health Care.

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Physicians Less Empathetic in Talking to Heavy Patients

THURSDAY, April 25 (HealthDay News) -- Primary care physicians (PCPs) are less likely to bond with overweight and obese patients, according to research published online March 20 in Obesity.

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Air Pollution Linked to Marker of Atherosclerosis

THURSDAY, April 25 (HealthDay News) -- Greater exposure to air pollution is associated with greater progression of carotid artery thickness, a marker of atherosclerosis, according to a study published online April 23 in PLOS Medicine.

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One 12-Ounce Sweet Drink a Day Ups Risk of T2DM 22 Percent

THURSDAY, April 25 (HealthDay News) -- Consumption of sweetened soft drinks correlates with the incidence of type 2 diabetes in European adults, with one 12-ounce daily increase in sweetened soft drinks correlating with a 22 percent increase in risk of the disease, according to a study published online April 25 in Diabetologia.

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Teens Targeting Strength, Cardio Fitness Battle Insulin Resistance

THURSDAY, April 25 (HealthDay News) -- Lower levels of abdominal muscle strength and cardiorespiratory fitness (CRF) in youth are independently associated with adverse levels of fasting insulin, insulin sensitivity, and β-cell function in young adulthood, according to a study published online April 11 in Diabetes Care.

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Diabetes Target Achievement Up From 1999 to 2010, More Needed

WEDNESDAY, April 24 (HealthDay News) -- For U.S. adults with diabetes there has been an improvement in achievement of targets from 1999 to 2010, but many still do not meet the recommended goals, according to research published in the April 25 issue of the New England Journal of Medicine.

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AMA Reveals First Step Toward Improving Health Outcomes

WEDNESDAY, April 24 (HealthDay News) -- The American Medical Association (AMA) has announced the first stage of its improving health outcomes initiative, which aims to optimize the health of the nation with a focus on preventing cardiovascular disease and type 2 diabetes.

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Diagnostic Errors Are the Leading Type of Malpractice Claim

WEDNESDAY, April 24 (HealthDay News) -- In the past 25 years, diagnostic errors have been the leading type of malpractice claim and account for the highest proportion of total payments, according to a study published online April 22 in BMJ Quality & Safety.

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Patient Characteristics Impact CABG-PCI Treatment Effect

TUESDAY, April 23 (HealthDay News) -- In the community setting, coronary artery bypass graft (CABG) surgery is associated with reduced mortality versus percutaneous coronary intervention (PCI), with the association affected by patient-level characteristics, according to a study published in the April 23 issue of the Annals of Internal Medicine.

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Behaviors Indicative of More Trips to Buffet Table Identified

TUESDAY, April 23 (HealthDay News) -- Surveying the food options before eating and using a smaller plate could result in less trips to the buffet at all-you-can-eat restaurants and buffets, according to a research letter published in the April issue of the American Journal of Preventive Medicine.

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Food-Tied Parenting Practices Common in Parents of Teens

MONDAY, April 22 (HealthDay News) -- The use of controlling food-related parenting practices, including food restriction and pressure-to-eat, are common among parents of adolescents and vary according to weight status, according to a study published in online April 22 in Pediatrics.

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Teen Type 1 Diabetes Outcomes Up With Internet Interventions

MONDAY, April 22 (HealthDay News) -- Internet-based psycho-educational programs are beneficial for young patients with type 1 diabetes as they transition into adolescence, according to a study published online April 11 in Diabetes Care.

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Community Gardening Programs Linked to Lower BMI

FRIDAY, April 19 (HealthDay News) -- Male and female participants in community gardening programs have significantly lower body mass indexes (BMIs) than their neighbors and siblings, according to a study published online April 18 in the American Journal of Public Health.

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Hair Analysis Can Show Elevated Cortisol Levels

FRIDAY, April 19 (HealthDay News) -- Elevated levels of the stress hormone cortisol, detectable in hair samples, is associated with increased risk of cardiovascular disease, according to a study published online April 17 in the Journal of Clinical Endocrinology & Metabolism.

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Patient-Centered Decision Making Ups Health Outcomes

FRIDAY, April 19 (HealthDay News) -- Patient-centered decision making (PCDM) is associated with improved health care outcomes, according to a study published in the April 16 issue of the Annals of Internal Medicine.

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Pot Smoking Linked to Some Metabolic Changes

FRIDAY, April 19 (HealthDay News) -- Regularly smoking pot is associated with visceral adiposity and adipose tissue insulin resistance, but not other metabolic changes such as impaired β-cell function or hepatic steatosis, according to a study published online March 25 in Diabetes Care.

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NH-proBNP Strongly Predicts Cardiac Mortality in T2DM

THURSDAY, April 18 (HealthDay News) -- NH2-terminal probrain natriuretic peptide (NT-proBNP) predicts the risk of cardiovascular (CV) mortality in patients with type 2 diabetes without previous CV disease (CVD), according to a study published online April 5 in Diabetes Care.

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Family-Centered Teaching Rounds Good for Patients, Students

THURSDAY, April 18 (HealthDay News) -- Teaching and conducting rounds in the presence of patients and their families can be beneficial for patients and learners, according to research published online April 15 in Pediatrics.

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Guidelines Issued Relating to Online Medical Professionalism

THURSDAY, April 18 (HealthDay News) -- Physicians should be aware of the benefits on online media and should recognize the implications for patient confidentiality and public perception, according to a position paper published in the April 16 issue of the Annals of Internal Medicine.

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Relative Proportion of MRSA Increasing in S. aureus Isolates

THURSDAY, April 18 (HealthDay News) -- The relative proportion of methicillin-resistant Staphylococcus aureus (MRSA) is increasing in S. aureus isolates, and methicillin-sensitive S. aureus (MSSA) is becoming increasingly resistant to antibiotics, according to a study published in the April issue of JAMA Dermatology.

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Essay Questions Conventional Etiology of Obesity

THURSDAY, April 18 (HealthDay News) -- To progress in the fight against obesity it is necessary to accept that there may be alternative hypotheses underlying its etiology and be prepared to invest the necessary time and resources to understand the underlying causes, according to an essay published online April 16 in BMJ.

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Vascular Markers Linked to Cognitive Decline in Diabetes

THURSDAY, April 18 (HealthDay News) -- Stroke and subclinical markers of macrovascular disease are associated with cognitive decline in older adults with type 2 diabetes, according to a study published online April 11 in Diabetes Care.

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Glutamine, Antioxidants No Benefit to Critically Ill Patients

WEDNESDAY, April 17 (HealthDay News) -- For critically ill patients with multiorgan failure, early supplementation with glutamine or antioxidants does not improve clinical outcomes, according to a study published in the April 18 issue of the New England Journal of Medicine.

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Community Benefit Spending Varies for Tax-Exempt Hospitals

WEDNESDAY, April 17 (HealthDay News) -- There is considerable variation in the level of community benefit expenditure by tax-exempt hospitals, according to a study published in the April 18 issue of the New England Journal of Medicine.

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High Resting Heart Rate Linked to Increased Mortality in Men

WEDNESDAY, April 17 (HealthDay News) -- For healthy middle-aged men, resting heart rate (RHR) is associated with an increased risk of mortality, according to a study published online April 17 in Heart.

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Low-Carb Diet Doesn't Improve Gestational Diabetes Outcomes

WEDNESDAY, April 17 (HealthDay News) -- A low carbohydrate (CHO) diet does not alter insulin needs or pregnancy outcomes in women with gestational diabetes mellitus (GDM), according to a study published online April 5 in Diabetes Care.

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Presenting Fee Data to Docs Cuts Number of Tests Ordered

WEDNESDAY, April 17 (HealthDay News) -- Presenting fee data to providers at the time of laboratory test orders is associated with a small reduction in the number of tests ordered, according to a study published online April 15 in JAMA Internal Medicine.

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Shock Waves Improve Coronary Stem Cell Treatment

TUESDAY, April 16 (HealthDay News) -- In patients with chronic heart failure, cardiac shock wave pretreatment before intracoronary infusion of bone marrow-derived mononuclear cells (BMCs) significantly but modestly improves heart function, according to a study published in the April 17 issue of the Journal of the American Medical Association.

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Overall Prevalence of Healthy Lifestyle Behaviors Is Low

TUESDAY, April 16 (HealthDay News) -- The prevalence of healthy lifestyle behaviors in patients with either a coronary heart disease (CHD) or stroke event is low in various countries with different income levels, but those living in poorer countries have the lowest prevalence, according to research published in the April 17 issue of the Journal of the American Medical Association.

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Activated Carotid Bodies Key in Metabolic Disruption

TUESDAY, April 16 (HealthDay News) -- Activation of carotid bodies (CB) by insulin may account for increased sympathoadrenal activity that results in insulin resistance (IR) and arterial hypertension, according to an experimental study published online March 25 in Diabetes.

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Endocrine Therapy Often Incomplete after Breast Cancer

TUESDAY, April 16 (HealthDay News) -- About 25 percent of women with breast cancer either never initiate adjuvant endocrine treatment or stop treatment prematurely, according to a study published in the March issue of Breast Cancer Research and Treatment.

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Routine CT Imaging Can Be Used to Identify Osteoporosis

TUESDAY, April 16 (HealthDay News) -- Abdominal computed tomography (CT) imaging, conducted for other indications, can be used to identify patients with osteoporosis, according to a study published in the April 16 issue of the Annals of Internal Medicine.

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USPSTF: Offer Preventive Meds to Women at Risk of Breast Cancer

TUESDAY, April 16 (HealthDay News) -- The U.S. Preventive Services Task Force recommends that women who are at increased risk of primary breast cancer consider taking preventive medications such as tamoxifen. This Recommendation Statement is based on an evidence review published in the April 16 issue of the Annals of Internal Medicine.

Draft Recommendation Statement
Comment on Recommendations
Background Review

Factors Weighing in on Long-Term Diabetes Survival Studied

MONDAY, April 15 (HealthDay News) -- Those able to survive with type 2 diabetes (T2DM) for more than 40 years are more likely to have better glycemic control, lower blood pressure, and more favorable lipid profiles, according to a study published online April 5 in Diabetes Care.

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Risk of New-Onset Diabetes Varies With Different Statins

THURSDAY, April 11 (HealthDay News) -- Different types and doses of statins seem to correlate with distinct risks of developing new-onset diabetes mellitus (DM), according to a meta-analysis published in the April 15 issue of The American Journal of Cardiology.

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Intensive Glucose Control Improves CVD Risk Factors

MONDAY, April 15 (HealthDay News) -- Intensive glucose-lowering therapy (INT) is associated with favorable changes in lipoprotein levels and inflammatory risk factors even though it does not lower the incidence of cardiovascular events, according to a study published online March 27 in Diabetes Care.

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4.4 mmol/L Is Optimal Fasting Glucose Cutoff for GDM Screening

MONDAY, April 15 (HealthDay News) -- A fasting plasma glucose value of 4.4 mmol/L is the optimal cut point for determining which pregnant Chinese women need a 75-g 2-h oral glucose tolerance test offered at 24 to 28 weeks' gestation, according to a study published online March 27 in Diabetes Care.

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Central Adiposity May Affect Renal Hemodynamics

FRIDAY, April 12 (HealthDay News) -- Regardless of body mass index (BMI), higher waist-to-hip ratio (WHR), a measure of central adiposity, is associated with lower glomerular filtration rate (GFR), lower effective renal plasma flow (ERPF), and higher filtration fraction (FF), according to research published online April 11 in Journal of the American Society of Nephrology.

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Vitamin D Not Tied to Subclinical Atherosclerosis in T1DM

FRIDAY, April 12 (HealthDay News) -- For individuals with type 1 diabetes, low concentrations of vitamin D metabolites are not associated with an increased risk of subclinical atherosclerosis, according to a study published online March 25 in Diabetes Care.

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Cardiac Function Unaffected by Prior Intensive Insulin Therapy

FRIDAY, April 12 (HealthDay News) -- There was no effect of intensive versus conventional insulin therapy during the Diabetes Control and Complications Trial (DCCT) on cardiac parameters as assessed by cardiac magnetic resonance (CMR) in the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort (follow-up to the DCCT), but prior glycemic exposure had an impact on cardiac parameters, according to research published online March 21 in Diabetes.

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Drug-Facilitated Weight Loss Benefits Cardiometabolic Status

FRIDAY, April 12 (HealthDay News) -- Obese and overweight patients with dyslipidemia or hypertension treated with phentermine and topiramate extended-release (PHEN/TPM ER) for weight loss had significant improvements in cardiovascular disease risk factors, according to research published in the April 15 issue of The American Journal of Cardiology.

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Restricting Soda Size May, Gulp, Actually Increase Consumption

THURSDAY, April 11 (HealthDay News) -- Restriction of larger-size sodas, which encourages conversion into bundles of smaller-sized sodas, may increase soda consumption, according to a study published online April 10 in PLOS ONE.

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Speech Details Practices to Improve U.S. Health Systems

THURSDAY, April 11 (HealthDay News) -- There are specific steps health care providers and policymakers should take to create high-quality, patient-centered care at lower costs, according to remarks made in an April 9 speech to the National Press Club.

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Overweight Adults Back Weight-Loss Health Benefits

THURSDAY, April 11 (HealthDay News) -- Most overweight adults feel that specific weight-loss benefits offered by health plans would be helpful, but few are willing to pay extra for them, according to a study published online April 9 in the American Journal of Preventive Medicine.

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Sales Representatives Provide Inadequate Safety Information

THURSDAY, April 11 (HealthDay News) -- Pharmaceutical sales representatives (PSRs) rarely inform primary care physicians about drug safety information during sales visits, according to research published online April 10 in the Journal of General Internal Medicine.

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Calorie Reduction, Not Bypass Surgery, Ups Diabetes Control

THURSDAY, April 11 (HealthDay News) -- Calorie reduction rather than the actual Roux-en-Y gastric bypass (RYGB) surgery seems to account for the improvement in glucose homeostasis in obese patients with type 2 diabetes who undergo RYGB, according to a study published online March 25 in Diabetes Care.

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Population-Wide Weight Loss, Gain Linked to Diabetes Burden

WEDNESDAY, April 10 (HealthDay News) -- Based on the Cuban experience of 1980 to 2010, population-wide weight loss and regain seem to correlate with the burden of diabetes and heart disease, according to a study published online April 9 in BMJ.

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Clinical Practice Guidelines for Bariatric Surgery Are Updated

WEDNESDAY, April 10 (HealthDay News) -- Based on a review of relevant evidence, 74 recommendations have been issued in updated clinical practice guidelines for bariatric surgery, according to a study published in the March issue of Surgery for Obesity and Related Diseases.

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Patients Using Different Rx Strategies to Save Money

TUESDAY, April 9 (HealthDay News) -- Adults in the U.S. who are poor or uninsured are more likely to ask for lower-cost alternatives or not to take their prescribed medications, according to research published in the April NCHS Data Brief.

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BMI at T2DM Diagnosis Has U-Shaped Link With Mortality

TUESDAY, April 9 (HealthDay News) -- For patients diagnosed with type 2 diabetes mellitus (T2DM), body mass index (BMI) around the time of diagnosis has a U-shaped correlation with mortality, according to research published in the April issue of Diabetes Care.

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Risk of Comorbidities Up With Hypoglycemia in T2DM

MONDAY, April 8 (HealthDay News) -- For patients with type 2 diabetes, hypoglycemia, regardless of its severity, correlates with a significantly increased risk of cardiovascular events, all-cause hospitalization, and mortality, according to research published in the April issue of Diabetes Care.

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Resveratrol Has No Effect in Healthy Obese Men, Study Finds

MONDAY, April 8 (HealthDay News) -- Resveratrol appears not to have a metabolic effect in obese men, according to a study published in the April issue of Diabetes.

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Growth Hormone Ups Height in Pediatric Dialysis Patients

FRIDAY, April 5 (HealthDay News) -- For pediatric dialysis patients, growth hormone (GH) therapy is associated with an increased rate of bone formation and results in greater increases in height, according to research published online April 4 in the Clinical Journal of the American Society of Nephrology.

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Diabetes Has Negative Impact on Individual's Ability to Work

FRIDAY, April 5 (HealthDay News) -- Diabetes has a negative impact on the ability to work, according to a review and meta-analysis published in the March issue of Diabetes Care.

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Diabetes-Linked Autoantibodies May Alter Children's Gut Microbes

FRIDAY, April 5 (HealthDay News) -- Children with diabetes-associated autoantibodies have alterations in the gut microbiome, according to a study published in the April issue of Diabetes.

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Walking Reduces CHD Risk Factors as Much as Running

FRIDAY, April 5 (HealthDay News) -- Equivalent energy expenditure by moderate- or vigorous-intensity exercise is associated with similar risk reductions in coronary heart disease risk factors, according to a study published online April 4 in Arteriosclerosis, Thrombosis, and Vascular Biology.

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Timing, Duration of Obesity Impact Adult Diabetes Risk

THURSDAY, April 4 (HealthDay News) -- The likelihood of diabetes in young adulthood is increased for those who are obese as adolescents and those with persistent obesity, compared to those with adult-onset obesity, according to a study published in the April issue of Diabetes Care.

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Primary Care Model Ups African Americans' Glycemic Control

THURSDAY, April 4 (HealthDay News) -- A primary care strategy targeting rural, low-income, African-American patients with type 2 diabetes is associated with improved glycemic control, according to research published in March/April issue of the Annals of Family Medicine.

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Prevalence of Self-Reported Hypertension Rises in U.S.

THURSDAY, April 4 (HealthDay News) -- The prevalence of self-reported hypertension among U.S. adults increased slightly, but significantly from 2005 to 2009, and the proportion of adults using anti-hypertensive medications also increased, according to research published April 4 in Morbidity and Mortality Weekly.

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Testosterone Changes Precede Type of Rheumatoid Arthritis

THURSDAY, April 4 (HealthDay News) -- Hormonal changes, especially testosterone, precede the onset of rheumatoid arthritis (RA) in men and may influence the type of RA, according to research published online April 3 in Annals of Rheumatic Diseases.

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Peer Coaching Model Beneficial for Patients With Diabetes

WEDNESDAY, April 3 (HealthDay News) -- Health coaching by peers is associated with a significant reduction in hemoglobin A1c (HbA1c) levels among patients treated in public health clinics, according to research published in the March/April issue of the Annals of Family Medicine.

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Cardiac Autonomic Dysfunction Is Linked to Arterial Stiffness

WEDNESDAY, April 3 (HealthDay News) -- Cardiac autonomic dysfunction as measured by lower heart rate variability (HRV) is associated with increases in both central and vascular vascular stiffness among youths with type 1 diabetes regardless of underlying cardiovascular disease (CVD) risk factors, according to research published online Feb. 22 in Diabetes Care.

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Decreased Melatonin Secretion Tied to Risk for Type 2 Diabetes

TUESDAY, April 2 (HealthDay News) -- In women, lower melatonin secretion is independently associated with a higher risk of developing type 2 diabetes, according to a study published published online April 2 in the Journal of the American Medical Association.

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Group-Based Weight Loss Incentives Are More Effective

TUESDAY, April 2 (HealthDay News) -- Group-based financial incentives for weight loss are more effective than individual incentives, according to a study published online April 1 in the Annals of Internal Medicine.

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Diabetes Affects Improvements After Lumbar Spine Surgery

TUESDAY, April 2 (HealthDay News) --Patients with diabetes who have longstanding diabetes, poor glycemic control, and use insulin had suboptimal improvements in clinical outcomes after lumbar spine surgery, according to research published March 15 in Spine.

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New Drug Approved for Type 2 Diabetes

MONDAY, April 1 (HealthDay News) -- Invokana (canaglifozin) has been approved by the U.S. Food and Drug Administration to treat type 2 diabetes, which affects about 24 million Americans.

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Diabetes Care for African-Americans Can Be Improved

MONDAY, April 1 (HealthDay News) -- For African-Americans with type 2 diabetes, health care-promoted interventions targeting patients, the health care system, or both, can improve the quality of care, according to a review and meta-analysis published in the March issue of Diabetes Care.

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Most Partners of U.S. Docs Satisfied in Their Relationships

MONDAY, April 1 (HealthDay News) -- Most spouses/partners of U.S. physicians report being satisfied with their relationships, with satisfaction linked to time spent together each day, according to research published in the March issue of the Mayo Clinic Proceedings.

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Runners Achieve Greater Weight Loss Than Walkers

MONDAY, April 1 (HealthDay News) -- Runners lose more weight than walkers, according to a large study published in the April issue of Medicine & Science in Sports & Exercise.

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