ARCHIVE SEARCH
      -OR-  
 
  NEWS CHANNELS
Fitness News
Asthma Allergy News
 > Diabetes News
Women's Health News
Men's Health News

  MY NEWS
Personal Archive
My Account

  ABOUT THIS NEWSFEED
About Us
Advertise With Us
Feed Your Site
Contact Us


Site Map
RSS News Feed 

  Website development & hosting
   by Cyber Software Solutions

 
Immune Intervention Reduces β-Cell Death in Type 1 Diabetes
Improvement in C-peptide responses seen with teplizumab; associated with decreased β-cell death

MONDAY, Feb. 25 (HealthDay News) -- Patients recently diagnosed with type 1 diabetes have greater death of pancreatic β-cells compared with patients with long-standing diabetes, which can be reduced by treatment with teplizumab, according to a study published online Feb. 19 in Diabetes.

Jasmin Lebastchi, from the Yale University School of Medicine in New Haven, Conn., and colleagues compared β-cell death in 43 patients recently diagnosed with type 1 diabetes, 31 individuals without diabetes, and 37 patients with type 1 diabetes treated with teplizumab or placebo. β-cell death was determined by measuring relative levels of unmethylated INS DNA in serum.

The researchers found that, compared with individuals without diabetes, patients with recent-onset diabetes had higher rates of β-cell death, while patients with long-standing diabetes had lower levels of β-cell death. After treatment of recent-onset diabetes patients with teplizumab, β-cell death was significantly reduced and β-cell function was significantly better preserved.

"Improvement in C-peptide responses with immune intervention is associated with decreased β-cell death," Lebastchi and colleagues write.

Several authors have patent applications for teplizumab and/or the assay of unmethylated insulin DNA and are on the scientific advisory board of Islet Sciences.

Abstract
Full Text (subscription or payment may be required)



Health News Copyright © 2013 HealthDay. All rights reserved.


Back to Top Stories
  GOOGLE ADS